The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis

Infiltrating CD4 and CD8 T cells have been shown to worsen inflammatory liver damage in non-alcoholic steatohepatitis (NASH). Inhibitory T cell receptors such as the programmed cell death protein 1 (PD1) and the natural killer cell receptor 2B4 regulate the activity of CD4 and CD8 T cells and theref...

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Vydáno v:Front Pharmacol
Hlavní autoři: Hansel, Cordula, Erschfeld, Stephanie, Baues, Maike, Lammers, Twan, Weiskirchen, Ralf, Trautwein, Christian, Kroy, Daniela C., Drescher, Hannah K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436071/
https://ncbi.nlm.nih.gov/pubmed/30949049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00244
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