Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells

Directed differentiation of human induced pluripotent stem cells (iPSCs) toward hepatobiliary lineages has been increasingly used as models of human liver development/diseases. As protein kinases are important components of signaling pathways regulating cell fate changes, we sought to define the key...

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Udgivet i:Stem Cells
Main Authors: CHAUDHARI, POOJA, TIAN, LIPENG, KIM, AMY, ZHU, QINGFENG, ANDERS, ROBERT, SCHWARZ, KATHLEEN B., SHARKIS, SAUL, YE, ZHAOHUI, JANG, YOON-YOUNG
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435276/
https://ncbi.nlm.nih.gov/pubmed/30471152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2950
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