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Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in Leishmania
Leishmania parasites lack pathways for de novo purine biosynthesis. The depletion of purines induces differentiation into virulent metacyclic forms. In vitro, the parasites can survive prolonged periods of purine withdrawal changing their morphology to long and slender cells with an extended flagell...
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| Publicado no: | PLoS Negl Trop Dis |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6435199/ https://ncbi.nlm.nih.gov/pubmed/30870425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007237 |
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