Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia

Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of lactate energetically couples astrocytes and neurons and supports brain bioenergetics. We examined the concentration of lactate...

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Udgivet i:Sci Rep
Main Authors: Sullivan, Courtney R., Mielnik, Catharine A., Funk, Adam, O’Donovan, Sinead M., Bentea, Eduard, Pletnikov, Mikhail, Ramsey, Amy J., Wen, Zhexing, Rowland, Laura M., McCullumsmith, Robert E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433855/
https://ncbi.nlm.nih.gov/pubmed/30911039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41572-9
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