Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

Huntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene, causing the protein to misfold and aggregate. HD progression is characterized by motor impairment and cognitive decline associated with the preferential loss of striatal medium spi...

Full description

Saved in:
Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Intihar, Taylor A., Martinez, Elisa A., Gomez-Pastor, Rocio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433789/
https://ncbi.nlm.nih.gov/pubmed/30941017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00103
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items