BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia

Bardet–Beidl syndrome (BBS) manifests from genetic mutations encoding for one or more BBS proteins. BBS4 loss impacts olfactory ciliation and odor detection, yet the cellular mechanisms remain unclear. Here, we report that Bbs4(-/−) mice exhibit shorter and fewer olfactory sensory neuron (OSN) cilia...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Uytingco, Cedric R., Williams, Corey L., Xie, Chao, Shively, Dana T., Green, Warren W., Ukhanov, Kirill, Zhang, Lian, Nishimura, Darryl Y., Sheffield, Val C., Martens, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432715/
https://ncbi.nlm.nih.gov/pubmed/30665891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.222331
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