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Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells

Spontaneous cell movement is underpinned by an asymmetric distribution of signaling molecules including small G proteins and phosphoinositides on the cell membrane. However, the molecular network necessary for spontaneous symmetry breaking has not been fully elucidated. Here, we report that, in Dict...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Main Authors: Fukushima, Seiya, Matsuoka, Satomi, Ueda, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432713/
https://ncbi.nlm.nih.gov/pubmed/30745337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.224121
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