The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development

Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements across developmental time. Embryonic loss of CDX2 triggers homeotic transformation of intestinal fate, whereas adult-onset loss compromises crucial physiological functions but preserv...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Kumar, Namit, Tsai, Yu-Hwai, Chen, Lei, Zhou, Anbo, Banerjee, Kushal K., Saxena, Madhurima, Huang, Sha, Toke, Natalie H., Xing, Jinchuan, Shivdasani, Ramesh A., Spence, Jason R., Verzi, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Human Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432663/
https://ncbi.nlm.nih.gov/pubmed/30745430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.172189
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