Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells

AIMS: Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) have become a promising tool in cardiovascular safety pharmacology. Immaturity of iPS-CMs remains an ongoing concern. We compared electrophysiological and contractile features of cardiac bodies (hiPS-CBs) derived from human-induced...

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Bibliografske podrobnosti
izdano v:Stem Cells Int
Main Authors: Trieschmann, Jan, Haustein, Moritz, Köster, Annette, Hescheler, Jürgen, Brockmeier, Konrad, Bennink, Gerardus, Hannes, Tobias
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431377/
https://ncbi.nlm.nih.gov/pubmed/30956672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6096294
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