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Effects of the potassium‐sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells
BACKGROUND: Osteosarcoma (OSA) is a common bone tumor of mesenchymal origin in dogs. Chemotherapy delays metastasis, yet most dogs die of this disease within 1 year of diagnosis. The high metabolic demand of cancer cells promotes proton pump upregulation, leading to acidification of the tumor microe...
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| Veröffentlicht in: | J Vet Intern Med |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430882/ https://ncbi.nlm.nih.gov/pubmed/30556178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvim.15382 |
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