Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography

A method for the simultaneous (one-step) photochemical conjugation and (89)Zr-radiolabeling of antibodies is introduced. A photoactivatable chelate based on the functionalization of desferrioxamine B with an arylazide moiety (DFO-ArN(3), [1]) was synthesized. The radiolabeled complex, (89)Zr-1(+), w...

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Gepubliceerd in:iScience
Hoofdauteurs: Patra, Malay, Klingler, Simon, Eichenberger, Larissa S., Holland, Jason P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430723/
https://ncbi.nlm.nih.gov/pubmed/30903963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.03.004
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