KIF5B-RET fusions in lung adenocarcinoma

We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene, which are present in 1–2% of lung adenocarcinomas (LADCs) from people from Japan and the United States, using whole-transcriptome sequencing. The KIF5B-RET fusion leads to aberrant activation of RET...

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Published in:Nat Med
Main Authors: Kohno, Takashi, Ichikawa, Hitoshi, Totoki, Yasushi, Yasuda, Kazuki, Hiramoto, Masaki, Nammo, Takao, Sakamoto, Hiromi, Tsuta, Koji, Furuta, Koh, Shimada, Yoko, Iwakawa, Reika, Ogiwara, Hideaki, Oike, Takahiro, Enari, Masato, Schetter, Aaron J, Okayama, Hirokazu, Haugen, Aage, Skaug, Vidar, Chiku, Suenori, Yamanaka, Itaru, Arai, Yasuhito, Watanabe, Shun-ichi, Sekine, Ikuo, Ogawa, Seishi, Harris, Curtis C, Tsuda, Hitoshi, Yoshida, Teruhiko, Yokota, Jun, Shibata, Tatsuhiro
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430196/
https://ncbi.nlm.nih.gov/pubmed/22327624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2644
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