Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes

How common polymorphisms in noncoding genome regions can regulate cellular function remains largely unknown. Here we show that cardiac fibrosis, mimicked using a hydrogel with controllable stiffness, affects the regulation of the phenotypes of human cardiomyocytes by a portion of the long noncoding...

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Gepubliceerd in:Nat Biomed Eng
Hoofdauteurs: Kumar, Aditya, Thomas, Stephanie K., Wong, Kirsten C., Lo Sardo, Valentina, Cheah, Daniel S., Hou, Yang-Hsun, Placone, Jesse K., Tenerelli, Kevin P., Ferguson, William C., Torkamani, Ali, Topol, Eric J., Baldwin, Kristin K., Engler, Adam J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430136/
https://ncbi.nlm.nih.gov/pubmed/30911429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-018-0344-5
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