Phase 1b/2a Trial of The Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-induced Oral Mucositis in Patients with Oral Cavity or Oropharyngeal Carcinoma

PURPOSE: Oral mucositis (OM) remains a critical problem; 70% of patients receiving chemoradiation (CRT) for oral cavity or oropharynx cancers (OCC) develop severe OM. Superoxide (O(2)•-) generated by CRT plays a significant role in initiating OM. Pre-clinical studies demonstrated that conversion of...

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Publicado en:Int J Radiat Oncol Biol Phys
Main Authors: Anderson, Carryn M., Sonis, Stephen T., Lee, Christopher M., Adkins, Douglas, Allen, Bryan G., Sun, Wenqing, Agarwala, Sanjiv S., Venigalla, Madhavi L., Chen, Yuhchyau, Zhen, Weining, Mould, Diane R., Holmlund, Jon T., Brill, Jeffrey M., Buatti, John M.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430109/
https://ncbi.nlm.nih.gov/pubmed/29174131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2017.10.019
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