KRAS and NRAS pyrosequencing screening in Tunisian colorectal cancer patients in 2015

BACKGROUND: Mutations in KRAS and NRAS often result in constitutive activation of RAS in the epidermal growth factor receptor (EGFR) signaling pathway. Mutations in KRAS exon 2 (codon 12–13) predict resistance to anti-EGFR targeted therapy in patients with metastatic colorectal carcinoma (mCRC). How...

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Bibliografiske detaljer
Udgivet i:Heliyon
Main Authors: Jouini, Raja, Ferchichi, Marwa, BenBrahim, Ehsen, Ayari, Imen, Khanchel, Fatma, Koubaa, Wafa, Saidi, Olfa, Allani, Riadh, Chadli-Debbiche, Aschraf
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430077/
https://ncbi.nlm.nih.gov/pubmed/30949599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e01330
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