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In Silico Methods for the Discovery of Orthosteric GABA(B) Receptor Compounds
The GABA(B) receptor (GABA(B)-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABA(B1a/b) and GABA(B2) subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABA(B1a/b) subunit. The receptor...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6429233/ https://ncbi.nlm.nih.gov/pubmed/30866507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24050935 |
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