Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity

Type I diabetes (T1D) is caused by immune-mediated destruction of pancreatic beta cells. This process is triggered, in part, by specific (aa 9–23) epitopes of the insulin Β chain. Previously, fish insulins were used clinically in patients allergic to bovine or porcine insulin. Fish and human insulin...

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Publicado no:Sci Rep
Main Authors: Foo, Kylie S., Skowronski, Alicja A., Baum, Danielle, Firdessa-Fite, Rebuma, Thams, Sebastian, Shang, Linshan, Creusot, Rémi J., LeDuc, Charles A., Egli, Dieter, Leibel, Rudolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428854/
https://ncbi.nlm.nih.gov/pubmed/30899071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40768-3
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