Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis

BACKGROUND: Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate receptor (NMDAR) complexes; however, larger samples are required to revea...

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Published in:Biol Psychiatry
Main Authors: Rees, Elliott, Carrera, Noa, Morgan, Joanne, Hambridge, Kirsty, Escott-Price, Valentina, Pocklington, Andrew J., Richards, Alexander L., Pardiñas, Antonio F., McDonald, Colm, Donohoe, Gary, Morris, Derek W., Kenny, Elaine, Kelleher, Eric, Gill, Michael, Corvin, Aiden, Kirov, George, Walters, James T.R., Holmans, Peter, Owen, Michael J., O’Donovan, Michael C.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428681/
https://ncbi.nlm.nih.gov/pubmed/30420267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2018.08.022
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