High subclonal fraction of 17p deletion is associated with poor prognosis in multiple myeloma

Deletions of chromosome 17p (del17p) that span the TP53 gene are associated with poor outcome in multiple myeloma (MM), but the prognostic value of del17p cancer clonal fraction (CCF) remains unclear. We applied uniform cytogenetic assessments in a large cohort of newly diagnosed MM (NDMM) patients...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Thakurta, Anjan, Ortiz, Maria, Blecua, Pedro, Towfic, Fadi, Corre, Jill, Serbina, Natalya V., Flynt, Erin, Yu, Zhinuan, Yang, Zhihong, Palumbo, Antonio, Dimopoulos, Meletios A., Gutierrez, Norma C., Goldschmidt, Hartmut, Sonneveld, Pieter, Avet-Loiseau, Herve
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428662/
https://ncbi.nlm.nih.gov/pubmed/30692124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-10-880831
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