A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific Tbx5-mutant mice demonstrate spontaneous AF. We report that TBX5 is critical for cellular Ca(2+) homeostasis, providing...

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Publicat a:eLife
Autors principals: Dai, Wenli, Laforest, Brigitte, Tyan, Leonid, Shen, Kaitlyn M, Nadadur, Rangarajan D, Alvarado, Francisco J, Mazurek, Stefan R, Lazarevic, Sonja, Gadek, Margaret, Wang, Yitang, Li, Ye, Valdivia, Hector H, Shen, Le, Broman, Michael T, Moskowitz, Ivan P, Weber, Christopher R
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Human Biology and Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428569/
https://ncbi.nlm.nih.gov/pubmed/30896405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41814
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