LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

The Mycobacterium tuberculosis kinase PknB is essential for growth and survival of the pathogen in vitro and in vivo. Here we report the results of our efforts to elucidate the mechanism of regulation of PknB activity. The specific residues in the PknB extracytoplasmic domain that are essential for...

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Publicado no:Nat Commun
Main Authors: Kaur, Prabhjot, Rausch, Marvin, Malakar, Basanti, Watson, Uchenna, Damle, Nikhil P., Chawla, Yogesh, Srinivasan, Sandhya, Sharma, Kanika, Schneider, Tanja, Jhingan, Gagan Deep, Saini, Deepak, Mohanty, Debasisa, Grein, Fabian, Nandicoori, Vinay Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428115/
https://ncbi.nlm.nih.gov/pubmed/30874556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09223-9
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