Metformin Improves Insulin Sensitivity and Vascular Health in Youth with Type 1 Diabetes: A Randomized Control Trial

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality in type 1 diabetes (T1D) and relates strongly to insulin resistance (IR). Lean and obese T1D adolescents have marked IR. Metformin improves surrogate markers of IR in T1D, but its effect on directly-measured IR and vascular h...

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Bibliographic Details
Published in:Circulation
Main Authors: Bjornstad, Petter, Schäfer, Michal, Truong, Uyen, Cree-Green, Melanie, Pyle, Laura, Baumgartner, Amy, Reyes, Yesenia Garcia, Maniatis, Aristides, Nayak, Sunil, Wadwa, R. Paul, Browne, Lorna, Reusch, Jane EB, Nadeau, Kristen J.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428045/
https://ncbi.nlm.nih.gov/pubmed/30566007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.035525
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