Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3(+) Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis

Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4(+)Foxp3(+) regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanis...

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Vydáno v:Front Immunol
Hlavní autoři: Abo, Hirohito, Flannigan, Kyle L., Geem, Duke, Ngo, Vu L., Harusato, Akihito, Denning, Timothy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428029/
https://ncbi.nlm.nih.gov/pubmed/30930900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00459
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