Cytoskeletal Control of Antigen-Dependent T Cell Activation

Cytoskeletal actin dynamics is essential for T cell activation. Here, we show evidence that the binding kinetics of the antigen engaging the T cell receptor influences the nanoscale actin organization and mechanics of the immune synapse. Using an engineered T cell system expressing a specific T cell...

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Publicat a:Cell Rep
Autors principals: Colin-York, Huw, Javanmardi, Yousef, Skamrahl, Mark, Kumari, Sudha, Chang, Veronica T., Khuon, Satya, Taylor, Aaron, Chew, Teng-Leong, Betzig, Eric, Moeendarbary, Emad, Cerundolo, Vincenzo, Eggeling, Christian, Fritzsche, Marco
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426652/
https://ncbi.nlm.nih.gov/pubmed/30893608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.074
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