Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice

Background: Inherited defects in adenosine deaminase (ADA) cause severe immune deficiency, which can be corrected by ADA enzyme replacement therapy (ERT). Additionally, ADA-deficient patients suffer from hearing impairment. We hypothesized that ADA-deficient (–/–) mice also exhibit hearing abnormali...

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Publicado en:Front Immunol
Autores principales: Xu, Xiaobai, Negandhi, Jaina, Min, Weixian, Tsui, Michael, Post, Martin, Harrison, Robert V., Grunebaum, Eyal
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424861/
https://ncbi.nlm.nih.gov/pubmed/30918508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00416
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