Direct activation of G-protein-gated inward rectifying K(+) channels promotes nonrapid eye movement sleep

STUDY OBJECTIVES: A major challenge in treating insomnia is to find effective medicines with fewer side effects. Activation of G-protein-gated inward rectifying K(+) channels (GIRKs) by GABA(B) agonists baclofen or γ-hydroxybutyric acid (GHB) promotes nonrapid eye movement (NREM) sleep and consolida...

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Bibliographic Details
Published in:Sleep
Main Authors: Zou, Bende, Cao, William S, Guan, Zhiwei, Xiao, Kui, Pascual, Conrado, Xie, Julian, Zhang, Jingxi, Xie, James, Kayser, Frank, Lindsley, Craig W, Weaver, C David, Fang, Jidong, Xie, Xinmin (Simon)
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Basic Science of Sleep and Circadian Rhythms
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424090/
https://ncbi.nlm.nih.gov/pubmed/30535004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsy244
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