Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution

High-resolution detection of genome-wide 5-hydroxymethylcytosine (5hmC) sites of small-scale samples remains challenging. Here, we present hmC-CATCH, a bisulfite-free, base-resolution method for the genome-wide detection of 5hmC. hmC-CATCH is based on selective 5hmC oxidation, chemical labeling and...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zeng, Hu, He, Bo, Xia, Bo, Bai, Dongsheng, Lu, Xingyu, Cai, Jiabin, Chen, Lei, Zhou, Ankun, Zhu, Chenxu, Meng, Haowei, Gao, Yun, Guo, Hongshan, He, Chuan, Dai, Qing, Yi, Chengqi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423965/
https://ncbi.nlm.nih.gov/pubmed/30278133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08297
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