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Novel Data Transformations for RNA-seq Differential Expression Analysis

We propose eight data transformations (r, r2, rv, rv2, l, l2, lv, and lv2) for RNA-seq data analysis aiming to make the transformed sample mean to be representative of the distribution center since it is not always possible to transform count data to satisfy the normality assumption. Simulation stud...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Zeyu, Yu, Danyang, Seo, Minseok, Hersh, Craig P., Weiss, Scott T., Qiu, Weiliang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423143/
https://ncbi.nlm.nih.gov/pubmed/30886278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41315-w
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