Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia

Gene correction of induced pluripotent stem cells (iPSCs) has therapeutic potential for treating homozygous familial hypercholesterolemia (HoFH) associated with low-density lipoprotein (LDL) receptor (LDLR) dysfunction. However, few data exist regarding the functional recovery and immunogenicity of...

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Publicado en:Sci Rep
Main Authors: Okada, Hirofumi, Nakanishi, Chiaki, Yoshida, Shohei, Shimojima, Masaya, Yokawa, Junichiro, Mori, Masayuki, Tada, Hayato, Yoshimuta, Tsuyoshi, Hayashi, Kenshi, Yamano, Tomoyoshi, Hanayama, Rikinari, Yamagishi, Masakazu, Kawashiri, Masa-aki
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423040/
https://ncbi.nlm.nih.gov/pubmed/30886174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41056-w
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