Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia

Gene correction of induced pluripotent stem cells (iPSCs) has therapeutic potential for treating homozygous familial hypercholesterolemia (HoFH) associated with low-density lipoprotein (LDL) receptor (LDLR) dysfunction. However, few data exist regarding the functional recovery and immunogenicity of...

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Vydáno v:Sci Rep
Hlavní autoři: Okada, Hirofumi, Nakanishi, Chiaki, Yoshida, Shohei, Shimojima, Masaya, Yokawa, Junichiro, Mori, Masayuki, Tada, Hayato, Yoshimuta, Tsuyoshi, Hayashi, Kenshi, Yamano, Tomoyoshi, Hanayama, Rikinari, Yamagishi, Masakazu, Kawashiri, Masa-aki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423040/
https://ncbi.nlm.nih.gov/pubmed/30886174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41056-w
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