Utility of cfDNA Fragmentation Patterns in Designing the Liquid Biopsy Profiling Panels to Improve Their Sensitivity

Genotyping of cell-free DNA (cfDNA) in plasma samples has the potential to allow for a noninvasive assessment of tumor biology, avoiding the inherent shortcomings of tissue biopsy. Next generation sequencing (NGS), a leading technology for liquid biopsy analysis, continues to be hurdled with several...

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Bibliographic Details
Published in:Front Genet
Main Authors: Ivanov, Maxim, Chernenko, Polina, Breder, Valery, Laktionov, Konstantin, Rozhavskaya, Ekaterina, Musienko, Sergey, Baranova, Ancha, Mileyko, Vladislav
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422983/
https://ncbi.nlm.nih.gov/pubmed/30915108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00194
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