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Dose tailoring of human cell line‐derived recombinant factor VIII simoctocog alfa: Using a limited sampling strategy in patients with severe haemophilia A

AIMS: The use of factor VIII (FVIII) prophylaxis in haemophilia A is considered the standard of care, particularly in children. Despite adjustment of doses for body weight and/or age, a large pharmacokinetic (PK) variability between patients has been observed. PK‐tailored prophylaxis may help clinic...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Delavenne, Xavier, Dargaud, Yesim, Ollier, Edouard, Négrier, Claude
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422655/
https://ncbi.nlm.nih.gov/pubmed/30633808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13858
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