Identification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity

Eosinophilia is a severe disease with increased eosinophil count. The transcript of FIP1L1-PDGFRA fusion gene is a genetic biomarker of clonal eosinophilia screened routinely by reverse transcript PCR (RT-PCR) during diagnosis. Another significant genetic biomarker is the PDGFRA gene alone as some o...

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Библиографические подробности
Опубликовано в: :Cancer Biol Ther
Главные авторы: Zhao, Miaomiao, Wu, Qiuling, Xia, Linghui, Zhang, Min, Yang, Jianqing, Li, Yaya, Tu, Shichun, Wang, Yadan
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2018
Предметы:
Bedside to Bench Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422476/
https://ncbi.nlm.nih.gov/pubmed/30359545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1532558
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