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Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma

BACKGROUND: Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor immunity and synergizes with radiotherapy. Clinical...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Neuro Oncol
Main Authors: Kieran, Mark W, Goumnerova, Liliana, Manley, Peter, Chi, Susan N, Marcus, Karen J, Manzanera, Andrea G, Polanco, Maria Lucia Silva, Guzik, Brian W, Aguilar-Cordova, Estuardo, Diaz-Montero, C Marcela, DiPatri, Arthur J, Tomita, Tadanori, Lulla, Rishi, Greenspan, Lianne, Aguilar, Laura K, Goldman, Stewart
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422437/
https://ncbi.nlm.nih.gov/pubmed/30883662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy202
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