Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

Mutations at the N- or C-terminus of C/EBPα are frequent in acute myeloid leukaemia (AML) with normal karyotype. Here, we investigate the role of the transcription factor Myb in AMLs driven by different combinations of CEBPA mutations. Using knockdown of Myb in murine cell lines modelling the spectr...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Principais autores: Volpe, Giacomo, Cauchy, Pierre, Walton, David S, Ward, Carl, Blakemore, Daniel, Bayley, Rachael, Clarke, Mary L, Schmidt, Luisa, Nerlov, Claus, Garcia, Paloma, Dumon, Stéphanie, Grebien, Florian, Frampton, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421631/
https://ncbi.nlm.nih.gov/pubmed/30877232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800207
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