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Major histocompatibility complex class I diversity limits the repertoire of T cell receptors

Major histocompatibility complex (MHC) genes encode proteins that initiate adaptive immune responses through the presentation of foreign antigens to T cells. The high polymorphism found at these genes, thought to be promoted and maintained by pathogen-mediated selection, contrasts with the limited n...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Migalska, Magdalena, Sebastian, Alvaro, Radwan, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421458/
https://ncbi.nlm.nih.gov/pubmed/30796191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807864116
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