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Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons

Phencyclidine (PCP) administration is commonly used to model schizophrenia in laboratory animals. While PCP is well-characterized as an antagonist of glutamate-sensitive N-methyl-D-aspartate (NMDA) receptors, its effects on dopamine signaling are not well understood. Here we used whole-cell and cell...

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發表在:Eur Neuropsychopharmacol
Main Authors: Piccart, Elisabeth, Tschumi, Christopher W., Beckstead, Michael J.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421099/
https://ncbi.nlm.nih.gov/pubmed/30686631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2019.01.108
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