A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4(+) T Cell Immune Response

BACKGROUND: A recombinant BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin 9K/129G (rBCG-S1PT), previously constructed by our research group, demonstrated the ability to develop high protection in mouse models of pertussis challenge which correlated with the induction o...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Kanno, Alex I., Goulart, Cibelly, Leite, Luciana C. C., Pagliarone, Ana C., Nascimento, Ivan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420988/
https://ncbi.nlm.nih.gov/pubmed/30941374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9630793
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