Loss of E-cadherin inhibits CD103 anti-tumor activity and reduces checkpoint blockade responsiveness in melanoma

Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant to checkpoint blockade display features of mesenchymal transition including E-cadherin loss. Here, we prese...

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Publicado no:Cancer Res
Main Authors: Shields, Bradley D., Koss, Brian, Taylor, Erin M., Storey, Aaron J., West, Kirk L., Byrum, Stephanie D., Mackintosh, Samuel G., Edmondson, Rick, Mahmoud, Fade, Shalin, Sara C., Tackett, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420873/
https://ncbi.nlm.nih.gov/pubmed/30674537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1722
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