Loss of E-cadherin inhibits CD103 anti-tumor activity and reduces checkpoint blockade responsiveness in melanoma

Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant to checkpoint blockade display features of mesenchymal transition including E-cadherin loss. Here, we prese...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Shields, Bradley D., Koss, Brian, Taylor, Erin M., Storey, Aaron J., West, Kirk L., Byrum, Stephanie D., Mackintosh, Samuel G., Edmondson, Rick, Mahmoud, Fade, Shalin, Sara C., Tackett, Alan J.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420873/
https://ncbi.nlm.nih.gov/pubmed/30674537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1722
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