Loss of E-cadherin inhibits CD103 anti-tumor activity and reduces checkpoint blockade responsiveness in melanoma

Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant to checkpoint blockade display features of mesenchymal transition including E-cadherin loss. Here, we prese...

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Vydáno v:Cancer Res
Hlavní autoři: Shields, Bradley D., Koss, Brian, Taylor, Erin M., Storey, Aaron J., West, Kirk L., Byrum, Stephanie D., Mackintosh, Samuel G., Edmondson, Rick, Mahmoud, Fade, Shalin, Sara C., Tackett, Alan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420873/
https://ncbi.nlm.nih.gov/pubmed/30674537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1722
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