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Treatment of female rhesus macaques with a somatostatin receptor antagonist that increases oocyte fertilization rates without affecting post-fertilization development outcomes

PURPOSE: To determine the effects of PGL1001, a somatostatin receptor isoform-2 (SSTR-2) antagonist, on ovarian follicle development, oocyte fertilization, and subsequent embryo developmental potential in the rhesus macaque. METHODS: Cycling female rhesus macaques (N = 8) received vehicle through on...

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Détails bibliographiques
Publié dans:J Assist Reprod Genet
Auteurs principaux: Ting, Alison Y., Murphy, Melinda J., Arriagada, Pablo, Gotteland, Jean-Pierre, Hennebold, Jon D.
Format: Artigo
Langue:Inglês
Publié: Springer US 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420531/
https://ncbi.nlm.nih.gov/pubmed/30430314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-018-1369-0
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