Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors

BACKGROUND: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the interstitial fluid pressure (PIF) in most solid tumors. An increased tumor PIF...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Smeland, Hilde Ytre-Hauge, Lu, Ning, Karlsen, Tine V., Salvesen, Gerd, Reed, Rolf K., Stuhr, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6419843/
https://ncbi.nlm.nih.gov/pubmed/30876468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5449-z
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