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Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration observed in Alzheimer’s disease (AD). We hypothesize that the initial insult originates in the lateral entorhinal cortex (LEC) due to deficits in key interneuronal functions and synaptic signaling mechanism...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Petrache, Alexandra L, Rajulawalla, Aarib, Shi, Anqi, Wetzel, Andrea, Saito, Takashi, Saido, Takaomi C, Harvey, Kirsten, Ali, Afia B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418384/
https://ncbi.nlm.nih.gov/pubmed/30766992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhz016
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