Elevated pre-activation basal level of nuclear NF-κB in native macrophages accelerates LPS-induced translocation of cytosolic NF-κB into the cell nucleus

Signaling via Toll-like receptor 4 (TLR4) in macrophages constitutes an essential part of the innate immune response to bacterial infections. Detailed and quantified descriptions of TLR4 signal transduction would help to understand and exploit the first-line response of innate immune defense. To dat...

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Publicado no:Sci Rep
Main Authors: Bagaev, Alexander V., Garaeva, Anastasiya Y., Lebedeva, Ekaterina S., Pichugin, Alexey V., Ataullakhanov, Ravshan I., Ataullakhanov, Fazly I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418260/
https://ncbi.nlm.nih.gov/pubmed/30872589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36052-5
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