Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation

A previously identified enhancer 10 kb upstream of the Aggrecan (Acan) gene (UE) can drive cartilage specific reporter expression in vivo. Here, we report that the paralogous transcription factors PAX1 and PAX9 differentially drive UE, depending on the presence or absence of SOX9-driven transactivat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Takimoto, Aki, Kokubu, Chikara, Watanabe, Hitomi, Sakuma, Tetsushi, Yamamoto, Takashi, Kondoh, Gen, Hiraki, Yuji, Shukunami, Chisa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418084/
https://ncbi.nlm.nih.gov/pubmed/30872687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40810-4
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