Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal

Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated negative factors produced by muscle drive neurodegen...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Gould, Thomas W., Dominguez, Bertha, de Winter, Fred, Yeo, Gene W., Liu, Patrick, Sundararaman, Balaji, Stark, Thomas, Vu, Anthony, Degen, Jay L., Lin, Weichun, Lee, Kuo-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417855/
https://ncbi.nlm.nih.gov/pubmed/30870413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007948
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