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APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
PURPOSE: Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids. PATIENTS AND METHODS: APOLLO-1 (NCT02815709) was a phase III, double-blind, randomized trial...
Kaydedildi:
| Yayımlandı: | J Pain Res |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Dove Medical Press
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6417853/ https://ncbi.nlm.nih.gov/pubmed/30881102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S171013 |
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