Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats

A fixed dose combination of lesinurad and allopurinol has been recently approved by USFDA and EMA for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone. In this study, an ultra-performance hydrophilic interaction liquid...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Iqbal, Muzaffar, Ezzeldin, Essam, Herqash, Rashed Naji, Alam, Ozair
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417734/
https://ncbi.nlm.nih.gov/pubmed/30870504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213786
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