Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues

The amyloid precursor protein (APP) is a type I transmembrane glycoprotein widely studied for its role as the source of β-amyloid peptide, accumulation of which is causal in at least some cases of Alzheimer’s disease (AD). APP is expressed ubiquitously and is involved in diverse biological processes...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Kulas, Joshua A., Franklin, Whitney F., Smith, Nicholas A., Manocha, Gunjan D., Puig, Kendra L., Nagamoto-Combs, Kumi, Hendrix, Rachel D., Taglialatela, Giulio, Barger, Steven W., Combs, Colin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417684/
https://ncbi.nlm.nih.gov/pubmed/30422705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00279.2018
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