Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

BACKGROUND: Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (PTX) in...

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Bibliographische Detailangaben
Veröffentlicht in:Chin Med
Hauptverfasser: Wang, Zhu, Yin, Jianhua, Li, Mingxing, Shen, Jing, Xiao, Zhangang, Zhao, Yueshui, Huang, Chengliang, Zhang, Hanyu, Zhang, Zhuo, Cho, Chi Hin, Wu, Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417206/
https://ncbi.nlm.nih.gov/pubmed/30911326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13020-019-0231-3
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