Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

BACKGROUND: Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (PTX) in...

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Detalhes bibliográficos
Publicado no:Chin Med
Main Authors: Wang, Zhu, Yin, Jianhua, Li, Mingxing, Shen, Jing, Xiao, Zhangang, Zhao, Yueshui, Huang, Chengliang, Zhang, Hanyu, Zhang, Zhuo, Cho, Chi Hin, Wu, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417206/
https://ncbi.nlm.nih.gov/pubmed/30911326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13020-019-0231-3
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