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Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

BACKGROUND: Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (PTX) in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Chin Med
Main Authors: Wang, Zhu, Yin, Jianhua, Li, Mingxing, Shen, Jing, Xiao, Zhangang, Zhao, Yueshui, Huang, Chengliang, Zhang, Hanyu, Zhang, Zhuo, Cho, Chi Hin, Wu, Xu
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417206/
https://ncbi.nlm.nih.gov/pubmed/30911326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13020-019-0231-3
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