Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma

BACKGROUND: Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target site homing of the delivery vehicles to the tumor microsatellite nests is chall...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Li, Man, Sun, Shoujia, Dangelmajer, Sean, Zhang, Quan, Wang, Junwen, Hu, Feng, Dong, Fangyong, Kahlert, Ulf D., Zhu, Mingxin, Lei, Ting
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417183/
https://ncbi.nlm.nih.gov/pubmed/30867058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1194-0
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