Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

BACKGROUND: Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8(wdl) mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcomi...

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Bibliografische gegevens
Gepubliceerd in:Neural Dev
Hoofdauteurs: Miterko, Lauren N., White, Joshua J., Lin, Tao, Brown, Amanda M., O’Donovan, Kevin J., Sillitoe, Roy V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417138/
https://ncbi.nlm.nih.gov/pubmed/30867000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13064-019-0130-4
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